Saturday, January 5, 2013

Rethinking bacterial persistence

Friday, January 4, 2013

It's often difficult to completely eliminate a bacterial infection with antibiotics; part of the population usually manages to survive. We've known about this phenomenon for quite some time, dating back nearly to the discovery of penicillin. For more than 50 years, scientists have believed that the resistant bacteria were individuals that had stopped growing and dividing.

Up to now, in fact, it hasn't been possible to track the growth of cells before and after their exposure to antibiotics, which makes any analysis of the phenomenon quite imprecise. "Using microfluidics, we can now observe every bacterium individually, instead of having to count a population," says John McKinney, director of EPFL's Microbiology and Microsystems Laboratory (LMIC).

Active survivors

This new tool has revealed quite a few surprises. "We thought that surviving bacteria made up a fixed population that stopped dividing, but instead we found that some of them continued to divide and others died. The persistent population is thus very dynamic, and the cells that constitute it are constantly changing ? even though the total number of cells remains the same. Because they're dividing, the bacteria can mutate and thus develop resistance in the presence of the antibiotic," explains LMIC scientist Neeraj Dhar.

This point is extremely important. "We were able to eliminate a purely genetic explanation of the phenomenon," continues Dhar. In other words, "a population of genetically identical bacteria consists of individuals with widely varying behavior. Some of them can adapt to stressors that they have not previously encountered, thanks to the selection of persistent individuals. This could lead to a revision of the entire theory of adaptation," says McKinney.

Intermittent efficiency

The EPFL scientists were particularly interested in a relative of the tuberculosis bacterium. Their observations enabled them to formally challenge the argument that persistent bacteria are those that have stopped growing and dividing. "We were able to reveal the role of an enzyme whose presence is necessary in order for the antibiotic to work, and show that the bacilli produced this enzyme in a pulsatile and random manner," explains Dhar. "Our measurements showed that bacterial death correlated more closely with the expression of this enzyme than with their growth factor." The research is being published this week in Science magazine.

These conclusions could mark the beginning of a new theory of bacterial resistance, or perhaps even introduce a new view of how such resistance evolves. Further research is being done using other microorganisms, such as tuberculosis and E. colibacteria. The persistence of some cancer cells to treatment could also be studied in a different manner. "It's a new approach for trying to figure out why some infections are so difficult to eliminate. The techniques we've developed for this study are now also being used to develop new antibiotics, in collaboration with pharmaceutical companies," says McKinney, adding that "it is the microengineering expertise at EPFL that has enabled us to create these innovative tools and open up new avenues for investigation."

###

Ecole Polytechnique F?d?rale de Lausanne: http://www.epfl.ch/index.en.html

Thanks to Ecole Polytechnique F?d?rale de Lausanne for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 46 time(s).

Source: http://www.labspaces.net/126133/Rethinking_bacterial_persistence_

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Friday, January 4, 2013

2012 'second wettest on record'

A look back at a year of extreme weather

The past 12 months were the second wettest on record in the UK, according to data released by the Met Office.

The total rainfall for the UK during 2012 was 1,330.7mm (52.4in), just 6.6mm short of the record set in 2000.

Most areas were affected by the extreme weather, with thousands of homes flooded and farmers struggling to grow crops in the saturated soil.

The latest data comes as analysis says the frequency of extreme rainfall in the UK may be increasing.

Continue reading the main story

Top five wettest years in the UK

1. 2000 - 1,337.3mm

2. 2012 - 1,330.7mm

3. 1954 - 1,309.1mm

4. 2008 - 1,295.0mm

5. 2002 - 1,283.7mm

(Source: Met Office)

BBC environment analyst Roger Harrabin said statistics showed that days of particularly heavy rainfall had become more common since 1960.

The study into extreme rain was based on statistics from the National Climate Information Centre, the UK's official climate record.

The Met Office said this was the wettest year on record for England, the third wettest for Wales, the 17th wettest on record for Scotland and the 40th wettest for Northern Ireland.

The records date back to 1910.

The Met Office added that four of the top five wettest years had occurred since 2000.

"The trend towards more extreme rainfall events is one we are seeing around the world, in countries such as India and China, and now potentially here in the UK," said Met Office chief scientist Prof Julia Slingo.

Continue reading the main story

Analysis


Although it has been the second wettest year on record for the UK, the start of the year was in fact dominated by talk of drought.

The big switch in weather conditions came as the 5th driest and 3rd warmest March on record gave way to the wettest April on record. We then experienced the wettest April to June on record, with June itself being the wettest June on record.

This drastic change was largely attributed to a shift in the position of the jet stream, a fast moving ribbon of air that flows high in the atmosphere. The jet stream helps create and steer low pressure systems towards and across the UK, and tends to meander from north to south through the year.

The extent of the jet stream's meandering largely results from the natural variability of our weather. During 2012, the jet stream was positioned to the south of the UK for extended periods of time.

This set-up resulted in the prevalence of Atlantic weather systems to be drawn across the UK from the west, bringing all the wet weather.

The wettest month of the year was December with 180.3mm of rain being recorded in the UK.

"Much more research is needed to understand more about the causes and potential implications."

Most areas in the UK experienced flooding during 2012, affecting thousands of homes and businesses.

In the run-up to Christmas, South-West England was particularly badly affected, with a number of railway lines remaining closed over the entire festive period.

The Environment Agency said almost 8,000 properties in England and Wales were flooded during 2012 and it sent more than 200,000 warnings to households and businesses.

However, it added that flood defences had protected more than 200,000 properties in at-risk areas.

'Double-whammy'

The rural economy was hardest hit by the poor weather, explained National Farmers Union (NFU) president Peter Kendall.

"The NFU estimates the appalling weather of 2012 has led to a financial black hole on Britain's farms amounting to a staggering ?1.3 billion," he said.

"As we enter 2013, many farmers are in areas under water or facing a double-whammy of huge feed bills for their livestock."

According to insurer NFU Mutual, weather-related claims from farmers were expected to exceed ?108 million but if the cost of reduced yields and failed harvests was also included then the final bill would be much higher.

Country Land and Business Association president Harry Cotterell said: "Farmers have lost valuable crops to the freak weather, which has had a knock-on impact for consumers as prices rise and produce becomes scarce and of poor quality."

The end of the year was in stark contrast to the beginning of 2012 when politicians, farmers and water industry officials held a "water summit" to look at supply concerns.

Areas in southern and South-East England were experiencing very low groundwater levels, prompting a number of water companies to impose hosepipe bans.

Institution of Civil Engineers Water Panel chairman Michael Norton said now was an ideal time to look at how the UK manages its water resources, in times of drought as well as during flooding events.

"The management of drought and flooding are interdependent and require a coherent strategy," he explained.

"Without a strategy, we will continue to swing from flooding to drought and climate change will only exacerbate the situation.

"There are many measures that can help us manage water more effectively from multipurpose reservoirs, storage ponds for agriculture, sustainable urban drainage systems, and household rainwater harvesting.

"But this requires a strategy bringing in all of the key players involved in water resource management and usage."

Mr Norton called on the government to establish a "UK Water Security Task Force" to provide the necessary leadership to deliver long-term water security.

Source: http://www.bbc.co.uk/news/science-environment-20898729#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Thursday, January 3, 2013

General Dynamics C4 Systems - SatNews.com

Satnews Daily January 02, 2013

General Dynamics... Still Going Strong With More'n 30,000 Fielded (Comms)

[SatNews] General Dynamics C4 Systems' recent delivery of 674 AN/PRC-112G? radios to the...

...U.S. Air Force included the 30,000th combat search and rescue (CSAR) radio fielded by General Dynamics. The PRC-112 radio, which is part of the HOOK2? CSAR system, has been connecting downed military pilots, aircrew and isolated personnel to search and rescue team members since the early 1980s.

The HOOK2 CSAR system includes the AN/PRC-112G radio which is carried by pilots, aircrew and special operations personnel, providing them with secure, two-way communications and automated alerts that help rescue crews identify and locate them quickly. The airborne component of the system, the Quickdraw2? Interrogator, is used aboard the search and rescue aircraft to locate the position of personnel and send secure responses back to the AN/PRC-112G radio. A satellite communications base station helps CSAR teams to locate and communicate with the AN/PRC-112G radio over long distances. In addition to the U.S. Department of Defense, the HOOK2 system is used by NATO and coalition partners in 29 countries.



Source: http://www.satnews.com/cgi-bin/story.cgi?number=201368083

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2012 Year in Review: News and Politics in Dallas | FrontBurner

2012 Year in Review: News and Politics in Dallas

The gift that keeps on giving.

We wrote about Rick Perry 64 times on this website this year. Wait, we wrote about Rick Perry 64 times this year, and used his name in the post. I?m sure a bunch more slipped in where Zac cloaked the Governor?s appearance. Anyway, that?s more than once a week. You can read all of them here. Thing is: that?s only half as much as we mentioned him in 2011. I guess my point is: Rick Perry is still the governor, and we?ll probably continue to drink from this chardonnay chalice until it?s dry.

In other news, we came up with a list of things to call the Margaret Hunt Hill Bridge, and Zac found out that she doesn?t like being called ?Large Marge.? JC Penney went gay, bike lanes became a thing, the City Council approved a boathouse, and we found out George W. Bush spends his days inside, painting dogs, like Howard Hughes or something. Susan G. Komen cut funding to Planned Parenthood, some folks tried to Save Winfrey Point, and Mayor Mike was forgainst the toll road.

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Speaking of Mayor Mike, what a year! He had all the black City Councilmembers walk out on him, he fire-bombed us with West Nile repellant (Zac caught up with one of the mosquitos), he got himself a fancy new golf course, planned a JFK assassination commemoration for the oldest people on the planet, and developed three personas (hint: they all love pizza). He also loved high-fives.

In the race for Texas? open U.S. Senate seat, former mayor Tom Leppert used his hands, and Craig James, in order: promised not to drop out of the race because it would disappoint God; took home 4 percent of the vote in the primary, less than the number of hookers he (allegedly) killed; dropped out of the race, presumably disappointing God; owed a bunch of people a lot of money. Oh and did Craig James Kill Five Hookers at SMU?

In presidential politics, Harold Simmons said Barack Obama was the most dangerous man in the country, and Chuck Norris thought the end times were nigh. After Obama won reelection, a bunch of people wanted to secede and started a social network for Texas secessionists, forcing normal people to petition the White House to not let Texas secede, because we would?ve become North Korea.

Rapid fire: women knitted uteri for Rick Perry, Dwaine Caraway hated sagging pants (but loves popcorn), John Wiley Price did a bunch of things people probably shouldn?t do, DISD hired a new superintendent who was promptly deep-fried for spending a ton of money on a communications head.

Oh and something happened with a tower made of museums, I think. I don?t know anything about it.

And we got a damn park.

Source: http://frontburner.dmagazine.com/2013/01/01/2012-year-in-review-politics/

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Wednesday, January 2, 2013

10 Reasons Why Public Relations is a 'Must-do' for SEO in 2013 ...

public-relations-word-cloud

Many people today recognize that search engine optimization (SEO) and public relations (PR) have much to offer each other.

The latest Google changes have put a real emphasis on high quality, unique content that is linked to by quality sites. And this is where real public relations ? as opposed to crappy news release distribution ? can play such a crucial role.

There are real opportunities for great business. What follows are 10 reasons why SEOs should really get to grips with PR in 2013, based on my conversations with the?people who are making the two work together.

1. The PR Industry is Definitely ?Getting it?

Most of us who have been in link building for a while have in the past experienced a certain degree of frostiness from the PR industry. But that is clearly changing and people are breaking out of silos.

Mike Cherenson is a former Chair and CEO of the Public Relations Society of America (PRSA) and is EVP of Success Communications Group. He sees the importance of SEO and link building.

?Authentic and relevant link building, aimed at driving engagement, informing publics and building mutually beneficial relationships should be a part of every public relations and SEO effort," Cherenson said.

But not only should link building be a part of every public relations effort, public relations also has much to offer SEO.

?Public relations professionals are skilled storytellers and content generators and should be a part of every SEO effort," he said. "The future of SEO is not in the technology, it?s in the ability to tell stories that readers and Google will find interesting? and that?s public relations.?

And Cherenson understands the value of linking.

?Links need to provide value to the reader," he said. "Media will be more likely to link to content that is compelling and provides information that goes beyond the original reporting.?

Another PR professional is Ken Deutsch, EVP of JPA, a healthcare communications firm and a seasoned specialist in public affairs.

His company takes SEO and link building very seriously. But that?s still not the case throughout the industry.

?Many PR people stop at getting media coverage and think their job is done. They get a placement in the New York Times but they don?t follow up to make sure a link is put in. So they?re not taking advantage of the SEO side of the story.?

And while many media outlets provide links, there are some that don?t link out as a matter of policy.

That influences the targets he goes after, ?because they don?t put links in, it?s not worth putting as much energy into getting placement there.?

2. There is a Tremendous Synergy Between SEO and PR

Putting it simply, SEO enhances a press release. Use popular keywords and the press release, never mind any stories it generates will continue to bring search engine traffic. And the editorial links the press release generates bring direct click-throughs and lead to higher rankings.

Public relations enhances SEO by focusing on what?s newsworthy, crafting a great story, finding editorial opportunities, getting coverage and building relationships with reporters and editors. And of course, they got the negotiation skills to ask for a link without really asking for a link.

?PR helps SEO directly by increasing branded traffic," said?Lindsey Kirchoff,?a Media and Speaker Relations specialist at HubSpot.com. "We always see a bump in branded traffic after a big campaign! Indirectly, PR helps SEO generate inbound links from quality sources that not only gets first-touch exposure to new audiences, but credibility in the eyes of search engines.

?SEO grounds PR with hard, measurable data. PR has always been notoriously difficult to pin down, but SEO adds hard numbers to the equation. I also think that SEO allows PR to be less isolated from the rest of the team ? sometimes PR can feel like an island. SEO helps PR connect their work to the rest of the company's business goals.

?Finally, SEO establishes credibility for PR for keywords. You look much more credible to a news source if you come up high for the term they are reporting on!?

3. Editorial Links Bring a Big SEO Boost

Most PR links are extreme quality links, according to Jordan Brannon, the SEO guy at Coalition Technologies. Why? "Because getting them is not a free for all ? you have to earn your media placements,? he said.

But the rewards are worth the effort.

?If you get 200 high quality editorial links, it?s worth more that 20,000 low quality links,? Brannon said.

However, most reporters work to a deadline and you have to be swift in your response to get in.

?Most editorial opportunities are time sensitive and you need to act quickly. That means you need to have the authority to reply on the client?s behalf," Brannon added. "And you have to have an email account on your client?s domain ? it?s not good saying you?re a marketing agency.?

Will Marlow was formerly a Press Secretary for two congressmen before founding a company that specializes in search engine marketing. He knows that to get those all-important editorial links, sticking to deadlines is crucial.

?You need to understand that you?re dealing with someone who has a hard deadline. It?s like a train going by in the night and there?s one open boxcar that can take you wherever you want to go," Marlow said. "But jump too early and the reporter won?t write about you: jump too late and the reporter won?t write about you. You got to get it just right.?

And it?s not unusual to miss opportunities.

?If an SEO was learning from any PR guy, they would all have stories about how they missed opportunities because someone internally didn?t get back to them or didn?t give the reporter what they need," Marlow said.??If the reporter wants to talk to the CEO and the CEO is playing golf, then you?re not going to get the story.?So you?ve got to collaborate with people within the company and make sure that the right people are available.?

4. There?s a Big Cascade Effect

Journalists will often quote, comment or enlarge upon other journalist?s work. Bloggers are also constantly citing other stories.

So if you get your story covered in one prominent media outlet, you?ll quickly see a cascade of similar stories and links spring up.

You?ll get links you never even asked for.

Miranda Miller wrote about How Google Rakes In Over $100 Million in Search Advertising Daily, based on research from Larry Kim of WordStream.

In writing that report, Kim was directly targeting the Wall Street Journal for a link ? and succeeded. The story really benefited from the cascade effect and attracted coverage and links from literally hundreds of quality media outlets.

5. You Win Bragging Rights For Your Client

Clients just love to write ?As featured in ..." on their website, whether its the Washington Post, Inc. Magazine, or whatever.

That builds consumer trust in their brand and makes it more likely they?ll buy.

And you also increase trust from other reporters. If you?ve already been quoted or covered by a respected publication, then other reporters will think you?re a safe bet to write about, too.

6. PR Skills Can be Learned ? or at Least Understood ? Easily

Kirchoff has this advice for SEOs who know little about PR:

?SEO experts should think of PR as a way to build strong referral links ? something that should be on their radar already. If you have a PR expert in the office, start by taking them out to lunch and chatting. After all, PR is all about building relationships.?

But of course, learning about public relations will help you understand the process ? but it might teach you that there?s a lot you don?t know. If that?s the case you might do better to partner with a PR resource.

7. It?s Easy to Partner With an Up and Coming PR Person

Mona Moore is an SEO who has teamed up with a small PR company, Hepner Communications, to pitch their services together.

?I think SEOs are always so focused on getting those links back to the client, we sometimes forget how important it is to nurture those long-term relationships necessary to continue working with specific media outlets,? Moore explained.??And PR reps are great at finding opportunities - but, they don't always take full advantage of those opportunities from an organic SEO standpoint.?By working together, SEOs and PR people are able to maximize exposure to a higher level than either of those entities by itself.

Joel Gross, who works with Brannon at Coalition Technologies, describes himself as the SEO tech guy.

?I know how to build and code websites so that they are search engine friendly, and I understand that in order to achieve visibility and revenue for our clients we need to build high quality links and work in tandem with traditional and social media," Gross said.??I know what needs to be done, but Jordan is able to bring in the creative aspect and wow factor that is needed in order to gain the attention and keep it focused where it needs to be. He devises how we frame the content and package it for the consumer in the most digestible and memorable way.

?The best advice I?d give to an SEO would be to get to know your client?s people, their background and story, what?s unique about the company," Gross said.??And remember, this is news and human interest so your stories don?t always have to be selling product. You can have perfectly good story and link from a story on say, ?work places that are pet friendly?!?

8. You?ll Build Media Contacts That You Can Use Time And Time Again

Contacts are essential both to PR people and to reporters.

?One mistake I made at the start was sending out too much poor stuff," Kim said. "Blasting out press releases is over-rated. What you need to do is get to know the reporters or bloggers you?re targeting.

?Read their articles every day, get a sense of what they?re interested in and only approach them with what you know they?ll be interested in,? Kim continued.??Start small and work your way up. Once you?ve built a relationship, they?ll start contacting you.?

He said he has found that PR is the fastest way to generate those backlinks on related industry websites, but you?ve got to go past distribution services and build your own contacts.

?We are diligent in keeping a database of related editors here," Kim said. "So we're sending press releases directly to the editors and not through a service. However, we also post the press releases to PRweb or PRnewswire to get the added Internet news site exposure (i.e., Yahoo News)."

Kim said those personal relationships increase the chances of coverage so much it?s "unreal."

"We now get lots of calls from editors who ask ? is there an engineer over at such and such a company that we could talk to?" Kim said.??Now, when they see our press releases, they always read them. And they?re more likely to publish them because we?ve been helpful.

If you?re an SEO who new to PR, the best place to start is by reading the editorial guidelines of the publications you?re targeting, Kim advised. Then you know what they?re looking for and can pitch accordingly. Don?t pitch something they clearly don?t want.

And don?t forget editorial calendars ? you can see months in advance what the publications are going to be covering.

9. It Strengthens and Extends Your Relationship With the Client

If you learn how to do proper public relations effectively or bring in a competent professional that you work well with, then you increase the respect your client has for your work. That can only strengthen your relationship and help ensure that they?ll stay with you.

10. It Opens up Additional Income Streams

It probably goes without saying that with the increasing interest in this area, it should offer some profitable and additional income streams to your agency.

There are tremendous publicity and quality links available through effective public relations. You?ll probably have failures to start with but if you keep at it, your skills will grow and you?ll get the benefits.

How do you cope with failures?

?I don?t believe in failures ? it?s a matter of setting your expectations," Kim said. "You can?t start out and immediately get coverage on CNN. Far better to pick a local target and learn from it. Every time you do it, you have more experience.?Say you approach 10 journalists and you get nothing but two reply and say I?m not interested because it?s not exactly what I do ? you?ll get a better idea of what will work next time.?


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Feb 18-21, 2013: The brightest and most insightful marketing minds in the industry will be gathering at SES London. Register today.

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Improve your Online Marketing Skills at SES New York!

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Source: http://searchenginewatch.com/article/2232614/10-Reasons-Why-Public-Relations-is-a-Must-do-for-SEO-in-2013

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Poor retail experience. | Bosco Anthony - Business Growth Strategist

Believe it or not the people representing your brand are crucial for the lifeline of your customers. I recently was reminded of this when I recently purchased a Kobo reader from a major book store during the Christmas break. I was at a different location and decided to try my luck at a different store from the usual one that I go to for convenience sake.

My troubles started with poor service from the sales associates who did not know how to read inventory. The perception was that he was trying to up sell and it was only when I pointed out that there was in deed 40 items of what I was looking for he sheepishly walked to the back to present my item. Upon purchase of the item there was no service, it was purely a transaction. As I walked out of the store I had realized that I had not passed my rewards cards during transactions as more sales associates will ask for this. So I had to stand in line to get this corrected. The lady informed me that this would take a few minutes and assured me my reward points would be added onto my account by the end of the night.

The next morning I checked my rewards account and found out that no points were added on this. On top of this I learned through checking my emails that the Kobo company had an exclusive deal where I would receive a gift card with the purchase of my reader. Not only did the sales associate fail to tell me this upon purchase I was not given the perks that I was supposed to receive with the purchase of my reader.

Upon calling the store I had to speak to representative at the store who could barely speak English and then passed me to someone who claimed to be the manager. His response was that I should come to the store to remedy the situation. I explained to him that this was an inconvenience for me to drive all the way back and asked if it was possible for me to go to another retail chain store closer to home to fix this. He said he would find out and call me back. The call never came and I had to call the store on my own initiative and remedy the situation.

After reaching out on the social networks and lambasting the company online I finally managed to get the chains attention. The bottom line in this entire retail experience is employees need to care about the brand. I love the brand but will probably never step into that store location again.

As some retail shoppers would say, ?Epic Fail!?

Source: http://www.boscoanthony.com/retail-experience/

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Tuesday, January 1, 2013

Orthopedic Foot and Ankle Center ? 2013 OFAC Health & Fitness ...

Welcome to the 2013?OFAC Health & Fitness Challenge. Getting started is the hardest part ? congratulations to everyone for signing up!

This year, Dr. Philbin has put a challenge together that will help you accomplish your fitness goals, while also encouraging us to work together. ??Registration has been strong with over 130 participants joining us from around the country.

We?ve heard your feedback from past years and have tailored the 2013 challenge to better assist you in meeting your goals. It?s our goal to keep everyone updated on the weekly point totals throughout the challenge and improving the communication during the entire challenge.

There are 3 components to the challenge scoring ??Each is worth 1/3 of your total score.

1. BodPod ? Improvement in body composition. (percent change from weigh in to weigh out)

2. Weekly Challenges ? points will be given weekly for completing.

3. D1 Fitness Assessment ? Improvement in?times and reps for each combine task.

FOLLOW THESE STEPS AND GET ON THE ROAD TO WINNING!

1. Work on improving your body composition by managing your diet and increasing exercise.

2. Complete the weekly challenges. The weekly challenges are designed to introduce some variety into your routine. Every Sunday evening the weekly challenge for the week will be posted on the OFAC blog and announced on the OFAC Facebook page. Complete the weekly challenge, then post a picture of yourself completing the challenge on the OFAC Facebook page (this is very important to ensure proper scoring).

The first weekly challenge will be the?First on the First 5K. If you cannot join us, feel free to run a 5K (3.1 miles) on your own. Don?t forget to take a picture of yourself completing the challenge as well as document your time. We will be using that time for comparison at the end of the challenge (hint, for another weekly challenge).

3. Improve your D1 fitness assessment times and reps with exercise, conditioning and practice.

The OFAC Facebook page is challenge headquarters ? use the page to share your accomplishments, post comments, ask questions, and most importantly logging your weekly challenge results. We look forward to celebrating everyone?s?accomplishments and announcing the winner at the challenge weigh out party in April (date & location to be provided). The 2013 winner will receive a $300 gift certificate to FootSourceMD.com and will have their name immortalized on the OFAC Health & Fitness Challenge trophy!

Good luck to everyone and have fun with the challenge.

Dr. Terry Philbin & the OFAC Health & Fitness Challenge Team

Source: http://www.orthofootankle.com/2012/12/2013-ofac-health-fitness-challenge-things-to-do-to-win/

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